Block1

=Cellular and Molecular Biology=

This block includes integrated topics from Biochemistry, Physiology, Microanatomy, Pharmacology and Pathology. The course begins with an introduction to cell structure and function, examining the details of the plasma membrane, cytoskeletal structure and cell organelles. This material includes integrated information about the molecular structure of amino acids, proteins, enzymes and lipids and functional considerations for cell-to-cell communications. It also includes a discussion of the basic tissue types and an introduction to pathologic changes which may affect them. The final portion of this course is dedicated to a discussion of molecular human genetics. The concepts of carcinogenesis, mutagenesis and genetic alteration, as well as an introduction to antineoplastic agents and gene therapy strategies, conclude the material to be presented.

=Schedule=



**Unit 1**
8-10 Orientation (Chakraborty) 10-12 Cell Intro (Chakraborty) 1-3 Proteins I (Williams) ||  || __Monday 8/27__ 8-10 Cell Motility (Crissman) 10-12 TCA Cycle (Manning) 1-3 Micro Lab Epithelial Tissue || 8-10 Proteins II (Williams) 10-12 Plasma Membrane I (Smas) 1-3 Epithelial Tissues (Crissman) ||  || __Tuesday 8/28__ 8-10 Cell Cycle (de la Serna) 10-12 TCA Cycle II (Manning) 1-3 Micro Lab Connective Tissue || //8-10 PBL// 10-12 Cytoskeleton/nucleus (Chakraborty) 1-3 Connective Tissue (Crissman) ||  || __Wednesday 8/29__ //8-10 PBL// 10-12 Myoglobin/Hemoglobin (Dignam) 1-4 Lab Quiz, Review, Q&A (Crissman) || 8-10 Plasma Membrane II (Smas) 10-12 Blood (Chakraborty) 1-3 Micro Lab Cytology ||  || __Thursday 8/30__ 8-10 Myoglobin/Hemoglobin, etc. (Dignam) 10-12 Electron Transport (Manning) 1-3 || 8-10 Mitochondria (Jacobus) 10-12 Proteins III (Williams) 1-3 Peer Mentoring Groups ||  || __Friday 8/31__ 8-10 Enzymes (Dignam) 10-12 Carbohydrates (Manning) 1-3 Review [|Vocab - what-where-why - Unit One.xls] [|Vocab - what-where-why - Unit One.csv] || around 144 questions** ||  ||   ||
 * __**Week 1**__ ||  || **__Week 2__** ||
 * __Monday 8/20__
 * __Tuesday 8/21__
 * __Wednesday 8/22__
 * __Thursday 8/23__
 * __Friday 8/24__
 * **Exam on 9/4, 9-11:30
 * **Exam on 9/4, 9-11:30

**Unit 2**
LABOR DAY// ||  || __Monday 9/10__ 8-10 Muscle 1 (Chiaia) 10-12 Gluconeogenesis (Manning) 1-3 Micro Lab Bone Development || UNIT 1 EXAM// ||  || __Tuesday 9/11__ 8-10 Muscle 2 (Chiaia) 10-12 Lipid Beta Oxidation (Maltese) 1-3 Glucogen Metabolism (Manning) || //8-10 PBL// 10-12 Glycolysis (Manning) 1-3 Cartilage (Crissman) ||  || __Wednesday 9/12__ //8-10 PBL// 10-12 Muscle 3 (Chiaia) 1-3 Review (Manning) || 8-10 Bone (Crissman) 10-12 Pentose Phosphate Pathway (Manning) 1-3 ||  || __Thursday 9/13__ 8-10 Neurocellular Structure (Chiaia) 10-12 Fatty Acid Synthesis (Maltese) 1-3 Muscle 4 (Lee) || 8-10 Bone Development (Crissman) 10-12 Interconversion of Hexoses (Manning) 1-3 Micro Lab Cartilage & Bone ||  || __Friday 9/14__ 8-10 Micro Lab Muscle and Nerve 10-12 Triacylglycerols (Maltese) 1-3 Lab Quiz, Intervention || [|Vocab 1.2.xls] Manning: ||  || __Review Materials__ [|Vocab 1.2 Week 4.xls] (Has Chiaia muscle and neuro vocab only, no lipids or Dr. Lee) || around 120 questions** ||  ||   ||
 * __**Week 3**__ ||  || __**Week 4**__ ||
 * //Monday 9/3
 * //Tuesday 9/4
 * __Wednesday 9/5__
 * __Thursday 9/6__
 * __Friday 9/7__
 * __Review Materials__
 * **Exam on 9/17, 9-11:00

**Unit 3**
UNIT 2 EXAM// ||  || __Monday 9/24__ 8-10 Coronary Heart Disease (Trumbly) 10-12 Cell Signalling (Sanchez) //1-3 FCP// || SELF-STUDY// ||  || __Tuesday 9/25__ 8-10 Amino Acids 2 (Dignam) 10-12 Dyslipidemia, Therapy (Trumbly) //1-5 Mandatory FCP Skill Session// || //8-10 PBL// 10-12 Phospholipids, Sphingolipids, Arachidonic Acid (Maltese) //1-4 FCP Orientation// ||  || __Wednesday 9/26__ //8-10 PBL// 10-12 RBC Metabolism 1 (Dignam) //1-3 Mandatory FCP Ethics// || 8-10 Cholestrol and Steroids (Maltese) 10-12 LIpid Digestion and Transport (Trumbly) //1-3 FCP// ||  || __Thursday 9/27__ 8-10 RBC Metabolism (Dignam) 10-12 Clinical Nutrition (Boardley) //1-5 Mandatory FCP Skill Session// || 8-10 Amino Acids 1 (Dignam) 10-12 Lipoprotein Metabolism (Trumbly) //1-3 FCP// ||  || __Friday 9/28__ 8-10 Heme Metabolism, Bile (Dignam) //10-12 FCP// 1-3 Intervention || [|RBC Metabolism Outline] || 8-10 RBC Disorders (White) 10-12 Weight Management (Boardley) 1-3 ||  ||   || 8-9 Heme Disorders (White) 9-10 Metabolic Syndrome/Diabetes (Trumbley) //10-12 FCP 1-5 Mandatory FCP Skill Session// ||  ||   || //8-10 PBL// 10-12 Case Studies (White) //1-5 Mandatory FCP Skill Session// ||  ||   || 8-10 PEM, Vitamins (Boardley) 10-12 Hemostasis and Bleeding (Smith) 1-3 ||  ||   || 8-10 Case Studies (Smith) 10-12 Review (Trumbly) 1-3 Intervention ||  ||   || around 117 questions** ||  ||   ||
 * __**Week 5**__ ||  || __**Week 6**__ ||
 * //Monday 9/17
 * //Tuesday 9/18
 * __Wednesday 9/19__
 * __Thursday 9/20__
 * __Friday 9/21__
 * __Review Materials__ ||  || __Review Materials__
 * __**Week 7**__ ||  ||   ||
 * __Monday 10/1__
 * __Tuesday 10/2__
 * __Wednesday 10/3__
 * __Thursday 10/4__
 * __Friday 10/5__
 * **Exam on 10/8, 9-11:00
 * **Exam on 10/8, 9-11:00

**Unit 4**
UNIT 3 EXAM// ||  || __Monday 10/15__ 8-10 DNA Replication 2 (Dignam) 10-12 RNA Transcription 1 (Ratnam) //1-5 Mandatory FCP Skill Session// || 8-10 Nucleotide Metabolism 1 (Trumbly) 10-12 Meiosis and Gametogenesis (Chakaborty) //1-3 FCP// ||  || __Tuesday 10/16__ 8-10 RNA Transcription 2 (Ratnam) 10-12 Mendelian Inheritance (Cicila) //1-5 Mandatory FCP Skill Session// || //8-10 PBL// 10-12 Nucleotide Metabolism 2 (Trumbly) //1-3 FCP// ||  || __Wednesday 10/17__ //8-10 PBL// 10-12 Protein Translation (Ratnam) //1-3 Mandatory FCP Ethics// || 8-10 Nucleic Acid (Dignam) 10-12 Chromosome Structure (Chakaborty) //1-3 FCP// ||  || __Thursday 10/18__ 8-10 Molecular Medicine (Micale) 10-12 Clinical Cytogenetics (Micale) 1-3 || 8-10 DNA Replication 1 (Dignam) 10-12 Folates and B12 (Trumbly) 1-3 Intervention ||  || __Friday 10/19__ 8-10 Recombinant DNA Tech (Trempe) 10-12 Multifactorial Inheritance (Cicila) 1-3 Intervention || 8-10 Genome Imprinting, Disomy, Disorders (Joe) 10-12 Gene Therapy //1-3 FCP// ||  || __Monday 10/29__ 8-10 Immunogenetics (Lee) 10-12 Molecular Basis of Disease (Cicila) || 8-10 Inborn Errors of Metabolism (Saad) 10-12 Population Genetics (Cicila) //1-3 FCP// ||  || //Tuesday 10/30 STUDY DAY// || //8-10 PBL// 10-12 Congential Abnormalities (Self-study) //1-3 FCP Ethics in Genetics// ||  || //Wednesday 10/31 UNIT 4 EXAM// || 8-10 Genetic Diseases (Self-study) 10-12 Mitochondrial Disorders, Genetic Linkage Analysis (Cicila) //1-3 FCP Ethics in Genetics// ||  || //Thursday 11/1 COMPREHENSIVE EXAM// || 8-10 Dysmorphology (Saad) 10-12 Pharmcogenetics, Review (Cicila) 1-3 Intervention ||  || //Friday 11/2 BLOCK 2 BEGINS// || around 144 questions** ||  || **Exam on 11/1, 10-11:15 75 Questions** Final Exam Review Materials ||
 * __**Week 8**__ ||  || __**Week 9**__ ||
 * //Monday 10/8
 * __Tuesday 10/9__
 * __Wednesday 10/10__
 * __Thursday 10/11__
 * __Friday 10/12__
 * __**Week 10**__ ||  || __**Week 11**__ ||
 * __Monday 10/22__
 * __Monday 10/22__
 * __Tuesday 10/23__
 * __Wednesday 10/24__
 * __Thursday 10/4__
 * __Friday 10/5__
 * **Exam on 10/31, 9-11:30
 * **Exam on 10/31, 9-11:30

=Old Exams=

Unit 4


=Old Material=

Units 1-4
2006 Block 1